Any One Tried PT-141 (Bremelanotide) for Libido and Erections?

    I’ve been reading about the peptide, PT-141. You can now buy it through Empower Pharmacy and other legit compounding pharmacies. It comes in both injectable and nasal forms. It is pretty expensive, over $200.  The research chemical places are much cheaper at $45-$50 per vial. But so many are frauds.

    From what I have read it can create and amazing increase in libido for both men and women and very hard and spontaneous erections in me.

    I’ve had no experience with it. Have any of you had experience with it?

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    9 Answer(s)

      I actually don’t have the link for this, but quite some time ago there was a thread here about some pop-culture woman that was older, I think in her 70’s, that was having sex 2x daily because her (older) husband requested it. I believe she was using PT-141. If I can think of what the thread was, I’ll come back and edit it into this answer.


      Edit: Found it quickly with the combination of Google and TMB’s search:  Would you pay to increase sexual frequency? (OT: I do miss STG’s contributions here.)

      Under the stars Answered on September 23, 2020.

      Yes. An old thread about Suzanne Somers.  I’m looking for some updated info and experiences. Thanks for responding.

      on September 23, 2020.
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        Ok so I have a lot of buddies/acquaintances involved in bodybuilding and strength training and many of them are steroid users. I myself being a believer don’t mess with illegal things so just know I’m not talking about myself.

        Peptides are pretty popular with steroid users and many of the use or have used melanotan (sp?) for skin color benefits which I believe pt141 is derived from. As such many of them were hip to screw with pt141 in hopes of catching the elusive libido side effect in melanotan.

        From the stories I heard they either ended up with an insatiable sexual appetite or conversely had hot flashes and intense nausea. Several of them warned that the desired effect seems to be very dose dependent and that they couldn’t find a pattern to determine who should take how much. They warned to start small and see what it did and if nothing don’t redose on the same day. Rather cut your losses and try again with a bit more another time.

        I’d like to reiterate that I haven’t tried this myself and this is pure “bro science” from my meathead buddies.

        Defy (whom I use and love for trt) will prooobably suggest a helpful dose as they are medical pros but if it were me deciding for myself I’d probably try a low dose for myself first.

        Please report back how PT141 works for you. If my wife was down to use a needle I’d be more inclined to try it. Also if you get benefit from the nasal administration DEFINITELY let us know!

        Good luck!

        Queen bed Answered on September 23, 2020.

        I’m just researching it now. Empower and Hallandale Pharmacies will have it available soon. Seems like the time that it kicks in varies with most saying it takes 4-6 hours. Some have nausea and some don’t.  Most report raging libido including women. The men also seem to have very strong erections over a 12 hour period.

        IF I try it, I’ll probably go through a research company because of the pricing. There does seem to be some reputable ones.

        on September 23, 2020.
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          Showing my age! When I saw PT-141, it reminded me of the very famous PT-109. In my youth, every young man dreamt of having a PT under his control! 😁😁

          If you know what I’m talking about you’re probably a Baby Boomer. For those unsure or curious here’s a link to the information about this fabulous creation and the fame behind it.

          Under the stars Answered on September 24, 2020.

          Right with you. The first thought that came to my mind when I saw the title of this thread is ‘where in the world would someone get a WW2 torpedo boat?’

          on September 24, 2020.
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            FDA approves new treatment for hypoactive sexual desire disorder in premenopausal women

            For Immediate Release:
            June 21, 2019

            This is Bremelanotide or what is commonly called PT-141. It is also effective for men. Here is the link to the  article:


            Hammock Answered on September 24, 2020.
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              The ExcelMale website has lots of personal comments on it’s use and effectiveness


              Hammock Answered on September 24, 2020.
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                I’ve been reading more studies and reviews on this. Most report very powerful results, although some have little or mild side effects. One reported nausea and vomiting.

                I’ve read reviews by ladies and they say that it definitely increases their libido and sensitivity. Men report strong, spontaneous erections. It’s different that ED meds because it works through your nervous system instead of blood flow. Many report almost euphoric feelings of love.

                Response time varies which makes it hard to gauge when it will take full effect. I’ll be having my 6 month check-up with Defy soon and will ask Nurse Jill about it. I wouldn’t be afraid to try it. Not sure about DW. Cost wise, Defy charges $205 for a 2 ml vial. Peptide companies charge about $45 for a 10 ml vial.

                Has anyone tried it?


                Hammock Answered on October 30, 2020.
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                  Here’s one study on PT-141’s effect on female libido


                  Bremelanotide for Female Sexual Dysfunctions in Premenopausal Women: A Randomized, Placebo-Controlled Dose-Finding Trial


                  In premenopausal women with HSDD, FSAD or both conditions, double-blind BMT self-administered subcutaneously on an at-home, as-desired basis over 12 weeks showed significant efficacy versus placebo, as demonstrated by an increase in the monthly number of SSEs (the study’s primary outcome measure) and by multiple other measures, both episodic and longer-term (longitudinal), with robust consistency. Although SSEs are a downstream measure of treatment effect [36], the study’s end points also included direct demonstration of increased sexual desire and arousal and decreased distress. Effective dosing with 1.25 and 1.75 mg was established. The dose of 0.75 mg did not differ from placebo (ineffective dose). The findings of this large Phase IIB trial provide further evidence of the safety and efficacy of BMT in premenopausal patients with FSAD and/or HSDD, and suggest that ongoing Phase III registration trials may confirm BMT as a significant as-desired treatment in this important, underserved patient population.

                  Hammock Answered on October 30, 2020.
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                    Although this doesn’t seem to be relevant to me at the moment, I really appreciate knowing that this is here if I need it in the future.

                    Under the stars Answered on October 30, 2020.

                    Thanks, SC. I’m not sure if I need it. either. It would be more recreational and maybe prepping for a future need. I read here about some who could perhaps benefit from this and bring some joy and life back to their MB.

                    I’m curious about this, but also know that so many supposed aphrodisiacs have not panned out. Defy is now prescribing it which gives it some credibility.

                    on October 30, 2020.
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                      UPDATE: Some have expressed an interest in my PT-141 experimentation.

                      I tried an initial small dose of 0.5 mg. I had some immediate flushing. Didn’t notice any nausea as I went back to bed.  I noticed no change as far as erection quality.

                      I will titrate the dosage up and see what happens. The next does will be 1.0 mg. Most sources say a dose of 1.5 – 2.0 is the most effective. Also, some say the more often you take it, the less side effects you’ll notice.

                      I will not ask DW to try it until I first see how it works with me.

                      Hammock Answered on December 2, 2020.
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