Do You Supplement with DHEA/Pregnenolone?
I have been supplementing my TRT with a compounded DHEA/Pregnenolone combo for years. It supposedly back-fills the hormonal pathways.
I can say that it makes me calmer and also helps me to sleep better. I take it at nigh before I go to bed.
Here is a link from the late Dr. John Crisler on DHEA:
What Is Pregnenolone?
Much more info at this link: https://articles.mercola.com/vitamins-supplements/pregnenolone.aspx
Pregnenolone is a steroid hormone synthesized from cholesterol. It is produced from the gonads, adrenal cortex3 and the brain,4 where it can be found in higher levels, compared to the blood.5
Essentially, pregnenolone is known for its anti-inflammatory properties that may help boost cognitive functions such as memory and learning, and to suppress depressive disorders.6 In fact, authors of a 1995 study considered it the “most potent memory enhancer” at the time.7
Pregnenolone is considered the grandmother, or root, of all other hormones, including:8
•Dehydroepiandrosterone (DHEA)9 — This hormone produces testosterone in men and estrogen in women.10 Both DHEA and pregnenolone provide beneficial effects to the central nervous system,11 and have been found to control behavioral activities and the function of GABAA receptors,12 which are responsible for most brain physiological functions.13
DHEA is also known to help boost glucocorticoid levels, which is necessary to help reduce the risk of depression.14 DHEA levels are high in the morning and low at night, similar to cortisol.15
•Progesterone — Also known as the pregnancy hormone, progesterone is essential in female reproductive functions such as menstrual cycle, implantation and pregnancy.16 It is the precursor to allopregnanolone, a hormone linked to mood swings in teenagers17 and negative mood symptoms in women with premenstrual dysphoric disorder.18
Dehydroepiandrosterone and Erectile Function: A Review
Full report here: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6119841/
DHEA plays an important role in sexual function. Low levels of DHEA were associated with a higher risk for ED in men [30,31] and low sexual responsiveness in women . It has also been speculated that DHEA plays a role in the process of erection. The Massachusetts Male Aging Study investigated 17 hormones, and DHEAS was the only one inversely correlated to ED prevalence . This data was later confirmed by another study, which demonstrated that DHEAS levels were significantly lower in men with ED in comparison to age-matched normal controls . The same group had demonstrated that DHEA treatment was associated with higher mean scores for each of the five domains of International Index of Erectile Function (IIEF) score .