Doctor prescribed estrogen cream; anything I should know?

    Had my first post-hysterectomy annual exam and mentioned a discomfort that I thought would turn out to be some sort of damage from the speculum or clamps or something that happened during the surgery–(thickening of injured tissue or something.) Turns out it’s just regular old menopausal discomfort in the opening of the vagina and I now have this cream I’m supposed to use nightly for 3 weeks, then as needed. (OBVIOUSLY, I’m not starting tonight!)

    Has anyone else done this? Any cautions, things to look out for? He warned us there’s no suddenly feeling frisky in the middle of the night after I’ve applied it.

    I made sure he knew it is very important to me (us) that we continue to be able to have a vibrant sex life as long as possible. (And what a great doctor God has blessed me with! He is able to put me totally at ease for talking about the most awkward things. He assures me he has heard it all and there is nothing I can talk about that will surprise him in the slightest. SO comforting when you need to bring up something awkward! IF YOU DON’T HAVE A DOCTOR LIKE THAT, CHANGE DOCTORS! It’s totally worth it!

    Under the stars Asked 6 days ago in Menopause .

    My estrogen levels were undetectable when my labs were drawn last May.
    I started estrogen cream last June from a compounding pharmacy thru Defy and my hot flashes disappeared within one week.
    My life has changed dramatically for the better.
    I apply the cream to my inner thighs a half an hour or so after my morning shower.
    I originally started using at night, but was concerned with transferring estrogen topically to DH during intimacy…..
    Since we’re not usually intimate in the am, I switched to morning applications.
    I rotate which leg I apply cream….and kinda duck walk around without clothing until it’s dry.
    I do believe my skin isn’t as fragile, and my emotions seem more “like me” since I started bhrt. The lack of hot flashes was my biggest blessing, everything else, a bonus.

    4 days ago.
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    7 Answer(s)

      As a breast cancer survivor, I continue to take estrogen suppressants so for those in the high risk estrogen positive cancer pool, please stay away.   For most women, not an issue.  Just know the family cancer (breast for us) history…my grandmother…my mother…and me (the only one with breast cancer pre menapausal).

      Double bed Answered 6 days ago.

      My paternal Grandmother had it when I was in high school. I’ll have to find the funeral card to remember when she was born (I am definitely NOT like Brynn’s DH described in the funny quirks question who remembers all that!!) and do some math to determine how old she was, but very likely past menopause. Also, she smoked like a chimney her whole life.

      I will have to do some research on my risk.

      Thank you for this!!

      5 days ago.

      For a 3 week course of therapy, I don’t think this is worth worrying about, as the increased cancer risk would be so small as to be impossible to measure. Obviously, if you were going to use the cream regularly on a permanent basis, then you should discuss this with your doctor.

      5 days ago.

      This is heartening. Thank you!

      1 day ago.
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        Take good notes, that way if/when I face it, I can glean wisdom from you! 🙂

        Under the stars Answered 6 days ago.
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          I love it…. i apply it at night. Every cell in the female body is bathed with estrogen and the vagina is the most greedy, there’s nothing really that can compensate for it however i am testing out DHEA as it’s supposedly is as good as estrogen in treating vaginal atrophy as it turns into either estrogen or testosterone in the tissues (very unscientific explanation)

          Fell out of ... Answered 6 days ago.
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            More help please!

            Okay:  I started the cream last night (I wanted to wait until Valentine’s weekend was over.) I love @SongOfAngels’ phrase “bathed with estrogen”, because that’s kind of exactly how it felt. Is it possible or merely a placebo effect that after only ten to fifteen minutes (maybe less) I began to feel physical arousal-type sensations that I have had difficulty achieving lately? I was really hoping to get those sensations back–had been in denial about them fading–but it doesn’t seem realistic to  be feeling, well, kinda horny just from applying the cream one time. SO not complaining!!

            The bigger question I have is:  will I absorb ALL of the hormone between one night and just before that time the next evening or is there danger of DH getting some on him? (Should we use a condom to be safe?) What if I skip a shower? What if I apply it at 11 p.m., after a shower, then we have sex early in the day the next day? Like a Friday night and Saturday afternoon or even morning? These things didn’t occur to me to ask my doctor. Didn’t anticipate the cream acting so fast!

            Under the stars Answered 1 day ago.
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              Using this source:, it looks like you might want to avoid latex condoms (though maybe the risk of a break is minor since you’re not going to be giving each other STI’s. As for the sex partner, you’re supposed to avoid exposing DH “right after” using it…whatever that means. Both of those come from the “Precautions” section at the above link.

              Interestingly, this academic study indicates that intercourse may lower your estradiol levels (somehow less uptake, or something else?) and can increase your DH’s.


              Fell out of ... Answered 1 day ago.
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                @Scott–Thanks. LOL, yeah, the condom thing is one of the best parts of being each other’s first-and-only:  we have never had even a half a moment’s concern about STIs. 😀

                It seems from the reading that hours later, after absorption, should be okay and just before the next dose even better. We’ve had so many hurdles to overcome lately I just don’t want to miss a single chance if it arises! Thanks for finding those for me.

                Under the stars Answered 1 day ago.
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                  My DW’s experience with estrogen inter-vaginaly has been good overall. She was beginning to have some dryness and pain. Post-menopausal. Applies it 2x a week. Other than being fairly expensive and uncovered by insurance, and a 24 hour post application sex hiatus, the effects have all been positive. I can even tell the difference.

                  She has had an estrogen sensitive phyloides breast tumor but her doctor has little concern.

                  Queen bed Answered 18 mins ago.
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