Topical estrogen usage

    I have searched quite a bit and can find no definitive answer to the question of how long to wait for intercourse post-application of vaginal estrogen. All you seem to get is a dubious “not immediately after.” It almost seems like nobody knows. There is absolutely nothing addressing this in the drug sheet I the package. GYN said nothing about it. Yet there are multiple warnings about getting it in contact with the penis causing feminizing effects. Some sites I’ve read state “always use a condom”, while others say “avoid condoms, etc because the oils could break them down.” That aspect I know is all about the STD concern, of which I have none. Some sites say “24 hrs,” other’s say “72 hrs.”

    Is there any published knowledge and practical guide I’ve missed out there? We’ve been practicing a 24 hrs rule and mostly that’s been workable. It caused some frustration recently so the subject is back on my mind. It is applied in the evening currently and is still leaking out into the next day – but how much of that is actual medication, or the carrier, or just increased natural fluids in response to the medication? Why is there no better, more specific info attainable?

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    8 Answer(s)

      I would absolutely love an answer as well!
      I currently use an estrogen cream prescribed by Defy, and I apply it to my inner thigh area daily as instructed. I do this early in the day because our intimate time is usually evening or night (though not always).
      The “not always” caveat made me research “how long after application is contact safe” and other various related searches.
      I got nothing.
      Even the Pharmacy that supplies my cream does not address this issue.
      So I understand both your question and your quandary….it’s as if no one will address it!!!!

      Queen bed Answered on August 9, 2019.
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        Have either of you asked your doctor or pharmicist this exact question? What did they say?

        Under the stars Answered on August 9, 2019.
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          “Consult the packaging”

          On the floor Answered on August 9, 2019.
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            Wifey uses progesterone cream which has a 45 minute “no-go” cooldown. The info we got from her compounding pharmacy also had the instructions for estrogen cream that I think gave a 1 hour prior and 4 hour after “no-go” timeframe. But, your pharmacy and cream may be different.

            California King Answered on August 9, 2019.
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              If you really want to know a definitive answer, call the manufacturer. I appreciate the question, though, since I will be making decisions about this in the near future.

              Under the stars Answered on August 11, 2019.

              Calling a generic manufacturer is a fools errand. Besides, you’d think if they had a position, they’d put it in the product pamphlet along with the seven pages of other useless information. It’s frustrating….

              There does seem to be some magic that happens at about 24 hours that hasn’t yet happened at 18.  It must disappear only within those last 6 hours. 

              on August 11, 2019.
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                LBD is using an estrogen cream that is placed inside her vagina. She does not want to get it on her husband.

                It should be applied after sex, before you go to sleep for the night. By morning sex should be OK.

                Vaginal estrogen cream is to treat the symptoms of low blood estrogen levels, such as vagina dryness. My wife had a hysterectomy and we used it for a short while.  It helped her vagina, but did nothing to correct the many other symptoms of low hormones.  So she went on bioidentical hormone replacement therapy (estrogen progesterone, and testosterone). We are now enjoying the best sex of our lives, and her general health is now good.

                So check out bHRT.  You will have to go to a doctor specializing in bHRT/life extension. The opinion of the mainstream medical community is that taking estrogen and testosterone is risky.  They do not know how to interpret lab results for hormone readings.  The “normal” range is a joke.  We researched it and believe the greater risk is in having low hormones. We have both been on it for around 10 years.

                Someone mentioned Defy Medical.  They provide treatment by phone consultation.  Everyone seems satisfied with them.  To find someone local go here

                Queen bed Answered on August 12, 2019.
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                  I’m with Defy.
                  I take progesterone (by mouth), testosterone (injection) thyroid (by mouth) and estradiol/estrogen topically.

                  Not a big fan of the delivery system with estrogen.

                  Queen bed Answered on August 13, 2019.

                  Yeah, that is surprising. I presume you are female since you are taking estrogen and because all worker bees are female :lol:. Typically women are given all three topically. Testosterone injections would theoretically work, but women generally absorb it thru the skin well.

                  I would not take progesterone orally.  Call defy about that. You can buy the cream OTC if that’s what it comes to. I take testosterone by injection and progesterone topically.

                  on August 13, 2019.
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                    Thought I’d update this question with some positive news.

                    DW has been on the topical stuff now for 6+ months and it has done good for her (and us.) Her natural lubrication has returned and she has no pain with intercourse. We have stuck with a 24 hour rule, but it causes little problem. We often have made it a habit to have sex just before she medicates in the evening, so the only miss is the next morning. I can live with loosing two mornings a week, no problem. She has tried putting it in at morning but it most all leaks out during the day. She still has some leak out with the evening application but very little.

                    I don’t know if I would give the estrogen credit for this, but our sex life in general is improving. So with all that being said, I would advocate it for anyone suffering post-menopausal dryness  and pain.

                    On the floor Answered on February 1, 2020.
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