Vitamin C – The Sex Vitamin?

    QUOTE: Vitamin C (ascorbic acid) “stimulate endothelial nitric oxide (NO) synthesis in a time- and concentration-dependent fashion.” [12] This basically means the more the Vitamin C, the more the nitric oxide.  Woo hoo!

    Could this all really be true?  Could such an inexpensive molecule as Vitamin C actually be a significant partner in helping men with their erectile dysfunction by boosting nitric oxide output, lowering blood pressure and increasing blood flow? The answer is a definitive ‘yes’.

    Add Comment
    6 Answer(s)

      People have been gobbling vitamin C to prevent colds for years. Have men who have done that noticed harder erections? I would think if that had been occurring as a surprise side effect, we would have heard about it.

      Under the stars Answered on March 6, 2020.
      Add Comment

        You can call me boorish and offensive if you like, but I am a scientist working in healthcare.

        Physiology and biochemistry are not my area, but an important part of my job is to critically read and appraise the scientific literature in order to enable clinical practice to be evidence based.

        I haven’t read every paper you’ve linked to, but some of those I have read have weaknesses which make me think that the evidence for supplementation isn’t as strong as you seem to think. Some of these weaknesses (on this and other topics related to supplements) are:

        1. use of observational studies – these may show an association, but that’s not the same as showing cause and effect. In particular, it’s unclear whether confounding variables have been identified and controlled for. It’s also possible that one variable may be a proxy for something else which is what’s really causing the effect.
        2. short duration studies – these may show a short-term effect, but give no information on whether that effect is maintained over a longer period.
        3. Lack of control groups – if you don’t have a control group, then you can’t be sure whether the effect would have been observed anyway
        4. small sample sizes – some of the samples were simply too small to reach robust
        5. specific patient groups – researchers generally look at a very well-defined group of people. It’s not always possible to extrapolate findings from that group to the general population. In particular, if you give men with erectile dysfunction an intervention that improves their erectile performance, it’s not clear that the same intervention will give an effect in men without erectile dysfunction.
        6. lack of data on dose response. Is there a safe upper limit above which supplements do harm, and if so what is it? Is there an upper limit above which additional supplementation gives no further effect? Is there a lower limit below which supplements have no effect? How do supplements interact with each other, or with prescription medications, and are there particular forms that give greater effectiveness? These questions are all unanswered.

        None of this is to say that supplements don’t work. However, I think further research needs to be done before I disagree with the official advice that supplementation has little or no proven benefits in people with a balanced diet.

        On the floor Answered on March 8, 2020.

        “Those who think they know it all have no way of finding out they don’t don’t.” – Leo Buscaglia

        on March 8, 2020.
        Add Comment

          @hoosier52, I think I owe you an apology. I looked at the two questions you posted today and when I followed the link and saw the site was a “news” site sponsored by a product for sale, I wondered if you were somehow connected to the product and promoting it under the guise of a supposedly impartial consumer. I looked back at your older answers and questions (as many as I could before getting the 4?4 Ops page) and now believe that is less likely than I first thought. I see that you have done a lot of research (from well-respected sources) in this area. I know I didn’t really “do” anything against you with my suspicious attitude, but I was a little dismissive of your post purely because you were sharing non-standard (not the same-old familiar facts) medical information and a lot of internet research. Then I realized I was kind of a hypocrite because just today, I myself introduced our family doctor to a disorder I suspect our DD suffers from. I learned about it from internet research, and I found it because I am motivated to keep looking past the “easy” “common” answers because I care about my daughter and “easy” and “common” answers just aren’t helping her.

          We dig for knowledge about what is most important to us.

          My DH hasn’t had any issues with ED so far, but I just might suggest he take some Vitamin D and make sure he eats plenty of citrus as a preventative measure. Thanks for sharing.


          Under the stars Answered on March 6, 2020.

          Duchess, your repentant approach to this is a great example to us all.


          on March 6, 2020.

          Duchess, thank you. I can understand why you may have thought that. I hope Dave will mimic your attitude. His comment was very offensive and uncalled for.  No worries. You’re good with me.

          Peak Testosterone is now run by the same man who runs ExcelMale. They do advertise for Defy Medical and Discount Labs. Someone has to pay the bills. Both sites have blogs which provide the best and most reliable information (IMO) information on male sexual problems on the web. I am not connected to them in any way. I just find them to be a great resource and when I see something that may help others here, I like to pas it along.

          Nigel Vergel, who now runs both sites since “Peak” was killed in a car accident is VERY strict about garbage info being posted. He will not tolerate it. He is the most knowledgeable person I’ve ever read after on TRT and related issues. Always backs his comments with reliable studies. Dr. Saya from Defy is a frequent poster.

          God bless you for your sweet and honest spirit. You have a new fan in me!

          on March 7, 2020.

          I’ve said before that the ExcelMale forum has been more helpful for T management with my husband than anywhere else. We were injecting 3x a week or every other day which a lot of men are doing but when i posted his tendency toward high SGBH, they suggested dropping back to twice weekly (something no other doctor or forum, probably) would know and it worked. They also advised me NOT to use an AI to lower his elevated Estrogen as it could crash him and recovery would be hell and they were right.

          on March 8, 2020.

          Song – I’ve seen your posts on ExcelMale. I must say that your husband is a blessed man to have a wife who takes such interest in his health and well-being. I agree, ExcelMale is a great source for learning about about male hormone and sexual issues.

          on March 8, 2020.
          Add Comment

            See the official UK guidance on this from the NHS


            Most people get enough vitamin C from their diet, and excessive vitamin C consumption can actually cause problems.

            Incidentally, I’m not saying that vitamin C doesn’t have a beneficial effect. What I am saying is that if you get enough vitamin C from your diet (which most of us do), then taking additional vitamin C is unlikely to have much of an effect because your kidneys will filter the excess and you’ll pass it in your urine because the body doesn’t store vitamin C.

            On the floor Answered on March 7, 2020.
            Add Comment

              Vitamin C is water soluble, so any excess is processed by your kidneys and excreted in urine.

              Please learn some science rather than trusting everything published online.

              On the floor Answered on March 6, 2020.

               Maybe you should learn some science before you make boorish comments. 

     – “Folic acid, calcium, vitamin C, and vitamin E support the biochemical pathways leading to NO release.  After production of NO and cyclic GMP are improved, use of phosphodiesterase-5 inhibitors should result in greater success in treating remaining erectile dysfunction. Recent studies have also suggested positive effects of phosphodiesterase-5 inhibitors on vascular function.

              CONCLUSION(S):  A multifaceted approach will maximize both erectile function and vascular health.

     Vitamin C works to boost blood flow, raise nitric oxide levels, lower blood pressure, and improve erectile dysfunction as well as libido. It can also lower cortisol and decrease inflammation. By lowering cortisol levels in menopausal women, Vitamin C can enhance the ability to maintain a healthy weight and lose excess body fat. (STUDY) The Journal of Biological Chemistry, Jan 5 2001, 276:40-47, “L-Ascorbic Acid Potentiates Endothelial Nitric Oxide Synthesis via a Chemical Stabilization of Tetrahydrobiopterin” Vitamin C also increases Citrulline Levels. Citrulline is a nutrient that is required to increase and sustain Nitric Oxide production, and it is vital to maintaining a healthy cardiovascular system. Men may also take Citrulline to improve erectile dysfunction. Interestingly, an in vitro study showed the Vitamin C can actually increase citrulline levels. (STUDY) The Journal of Biological Chemistry, Mar 19 1999, 274:8254-8260, “L-Ascorbic Acid Potentiates Nitric Oxide Synthesis in Endothelial Cells”  

     Vitamin C helps improve blood flow. Blood flow affects your erectile function, so vitamin C may help sexual function. Vitamin C can’t be stored in the body, so you need to eat enough foods rich in vitamin C every day. Good sources of vitamin C include:  

     Ascorbate (Asc) has been shown to increase nitric oxide (NO) bioavailability and thereby improve endothelial function in patients showing signs of endothelial dysfunction.  

     – Long Term Vitamin C Treatment Increase Nitric Oxide


              on March 6, 2020.
              Add Comment

                Doesn’t work for my H

                Blanket on a secluded beach! Answered on March 6, 2020.

                Have you considered Bimix or Trimix?

                on March 6, 2020.

                i might as some point although we go through his primary and idk about what he knows about it. We’re having reasonable results kind of w/daily Cialis plus i give him Beet Root powder w/Citrulline but lately have been trying TCM herbals which probably help the most but we haven’t had sex often enough lately (due to his pain/fatigue levels) to really tell yet.

                on March 7, 2020.

                I believe in supplements as you can see, but there is only so much benefit that they can provide. It would be worth asking your PCP about Bimix or Trimix.  I’ve red lots pf reviews and comments on both of them. The biggest issues are getting dialed in and the potential for priapism. For many, it is a life and marriage changer. One wife known as “The Trimix Lady” has older posts that give a wife’s perspective on it.

                BTW – I really appreciate your honest and informative posts. You’re one of the best on here.

                God bless!

                on March 7, 2020.

                Oh! Thank you! i don’t consider myself that at all, i’m constantly amazed at the intelligent well written brothers and sisters on this board and i’m one of the least!

                on March 8, 2020.
                Add Comment

                Your Answer

                By posting your answer, you agree to the privacy policy and terms of service.